Invention Grant
US08236548B2 Minicircle DNA vector preparations and methods of making and using the same
有权
小环DNA载体制剂及其制备和使用方法
- Patent Title: Minicircle DNA vector preparations and methods of making and using the same
- Patent Title (中): 小环DNA载体制剂及其制备和使用方法
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Application No.: US12497396Application Date: 2009-07-02
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Publication No.: US08236548B2Publication Date: 2012-08-07
- Inventor: Zhi-Ying Chen , Mark A. Kay
- Applicant: Zhi-Ying Chen , Mark A. Kay
- Applicant Address: US CA Palo Alto
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Palo Alto
- Agency: Bozicevic, Field & Francis LLP
- Agent Pamela J. Sherwood
- Main IPC: C12N1/21
- IPC: C12N1/21
Abstract:
The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest, a product hybrid sequence of a unidirectional site-specific recombinase, and are devoid of plasmid backbone bacterial DNA sequences. Also provided are methods of producing the subject formulations as well as methods for administering the minicircle nucleic acid vector formulations to a subject. The subject methods and compositions find use in a variety of different applications, including both research and therapeutic applications.
Public/Granted literature
- US20100075401A1 MINICIRCLE DNA VECTOR PREPARATIONS AND METHODS OF MAKING AND USING THE SAME Public/Granted day:2010-03-25
Information query
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