Invention Grant
- Patent Title: Compositions and methods for siRNA inhibition of HIF-1 α
- Patent Title (中): siRNA抑制HIF-1α的组成和方法
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Application No.: US12630077Application Date: 2009-12-03
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Publication No.: US08236775B2Publication Date: 2012-08-07
- Inventor: Samuel Jotham Reich , Enrico Maria Surace , Michael J. Tolentino
- Applicant: Samuel Jotham Reich , Enrico Maria Surace , Michael J. Tolentino
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Pepper Hamilton LLP
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/02 ; C07H21/04 ; C12Q1/68
Abstract:
RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer.
Public/Granted literature
- US20100136101A1 COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF HIF-1 ALPHA Public/Granted day:2010-06-03
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