Invention Grant
- Patent Title: Dual-acting antihypertensive agents
- Patent Title (中): 双作用抗高血压药
-
Application No.: US13330372Application Date: 2011-12-19
-
Publication No.: US08236839B2Publication Date: 2012-08-07
- Inventor: Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
- Applicant: Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A61K31/41
- IPC: A61K31/41 ; C07D257/04

Abstract:
The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20120088919A1 DUAL-ACTING ANTIHYPERTENSIVE AGENTS Public/Granted day:2012-04-12
Information query