Invention Grant
US08236850B2 Dimeric derivatives of artemisinin and application in anticancer therapy
有权
青蒿素的二聚衍生物和抗癌治疗中的应用
- Patent Title: Dimeric derivatives of artemisinin and application in anticancer therapy
- Patent Title (中): 青蒿素的二聚衍生物和抗癌治疗中的应用
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Application No.: US12808828Application Date: 2008-12-22
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Publication No.: US08236850B2Publication Date: 2012-08-07
- Inventor: Jean-Pierre Begue , Danielle Bonnet-Delpon , Benoît Crousse , Fabienne Grellepois , Constance Chollet , Jacques Fahy , Céline Mordant
- Applicant: Jean-Pierre Begue , Danielle Bonnet-Delpon , Benoît Crousse , Fabienne Grellepois , Constance Chollet , Jacques Fahy , Céline Mordant
- Applicant Address: FR Boulogne-Billancourt FR Paris FR Orsay
- Assignee: Pierre Fabre Medicament,Centre National de la Recherche Scientifique,Universite Paris-Sud 11
- Current Assignee: Pierre Fabre Medicament,Centre National de la Recherche Scientifique,Universite Paris-Sud 11
- Current Assignee Address: FR Boulogne-Billancourt FR Paris FR Orsay
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: FR0760266 20071221
- International Application: PCT/EP2008/068133 WO 20081222
- International Announcement: WO2009/080805 WO 20090702
- Main IPC: A61K31/337
- IPC: A61K31/337 ; C07D493/16 ; C07D321/02
Abstract:
The present invention relates to dimeric derivatives of 10-trifluoromethylated artemisinin of formula (I): or a pharmaceutically acceptable salt thereof with B1 and B2 selected from C═O, CHOH and CH2, as well as to their use in treating cancer and to their preparation method.
Public/Granted literature
- US20100266570A1 DIMERIC DERIVATIVES OF ARTEMISININ AND APPLICATION IN ANTICANCER THERAPY Public/Granted day:2010-10-21
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