Invention Grant
US08236927B2 Stabilizer molecule-depleted albumin solution 有权
稳定剂分子耗尽的白蛋白溶液

  • Patent Title: Stabilizer molecule-depleted albumin solution
  • Patent Title (中): 稳定剂分子耗尽的白蛋白溶液
  • Application No.: US11920015
    Application Date: 2006-05-11
  • Publication No.: US08236927B2
    Publication Date: 2012-08-07
  • Inventor: Katrin Stange
  • Applicant: Katrin Stange
  • Applicant Address: DE Rostock
  • Assignee: Albutec GmbH
  • Current Assignee: Albutec GmbH
  • Current Assignee Address: DE Rostock
  • Agent Michael L. Dunn
  • Priority: DE102005023155 20050513
  • International Application: PCT/EP2006/062234 WO 20060511
  • International Announcement: WO2006/120226 WO 20061116
  • Main IPC: A61K38/38
  • IPC: A61K38/38
Stabilizer molecule-depleted albumin solution
Abstract:
The invention concerns a method for producing an aqueous albumin solution from a starting albumin solution which contains stabilizer molecules which are capable of occupying binding sites of the albumin, wherein in a method for increasing the albumin binding capacity (ABiC) for other molecules, at least a portion of the stabilizer molecules is removed from the albumin of the starting albumin solution and separated from the starting albumin solution. To carry out such a method, by means of which a stabilized commercial starting albumin solution can be prepared in a manner which is simpler, faster, cheaper and in a manner which is gently on the albumin by removing the majority of the stabilizers and increasing the albumin binding capacity, the method comprises steps in which the starting albumin solution is brought into contact with a solid adsorption material the affinity of which for at least a portion, preferably all of the stabilizer molecules is higher than the affinity of the albumin for the corresponding stabilizer molecules, and the albumin is separated from the adsorption material; wherein the method is carried out at a pH of >3.
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