Invention Grant
US08236933B2 Modified animal lacking functional PYY gene, monoclonal antibodies that bind PYY isoforms and uses therefor
失效
缺乏功能性PYY基因的修饰动物，结合PYY亚型的单克隆抗体并用于其
- Patent Title: Modified animal lacking functional PYY gene, monoclonal antibodies that bind PYY isoforms and uses therefor
- Patent Title (中): 缺乏功能性PYY基因的修饰动物，结合PYY亚型的单克隆抗体并用于其
-
Application No.: US11911300Application Date: 2006-04-13
-
Publication No.: US08236933B2Publication Date: 2012-08-07
- Inventor: Herbert Herzog , Charles Mackay
- Applicant: Herbert Herzog , Charles Mackay
- Applicant Address: AU Darlinghurst, NSW
- Assignee: Garvan Institute of Medical Research
- Current Assignee: Garvan Institute of Medical Research
- Current Assignee Address: AU Darlinghurst, NSW
- Agency: Fenwick & West LLP
- Priority: AU2005901846 20050413; AU2006901306 20060314
- International Application: PCT/AU2006/000503 WO 20060413
- International Announcement: WO2006/108234 WO 20061019
- Main IPC: C07K16/26
- IPC: C07K16/26 ; G01N33/53 ; G01N33/74 ; C12N5/12
Abstract:
The present invention provides transgenic animals having a reduced level of expression of peptide YY (PYY) and drug screening platforms using the transgenic animals for identifying agonists and antagonists of PYY. The present invention further provides monoclonal antibodies that bind specifically to full-length PYY[1-36] or the processed form thereof i.e., PYY[3-36] and to diagnostic and drug screening platforms using the monoclonal antibodies. The invention has particular utility for the diagnosis of a predisposition or risk of a subject becoming obese, developing one or more pathologies associated with obesity, or developing a disease/disorder of bone tissue.
Public/Granted literature
Information query
