Invention Grant
US08236960B2 Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its tartrate salt and crystalline forms
有权
N-（4-氟苄基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙氧基）苯基甲基）脲和其酒石酸盐和结晶形式的合成
- Patent Title: Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its tartrate salt and crystalline forms
- Patent Title (中): N-（4-氟苄基）-N-（1-甲基哌啶-4-基）-N' - （4-（2-甲基丙氧基）苯基甲基）脲和其酒石酸盐和结晶形式的合成
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Application No.: US13081427Application Date: 2011-04-06
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Publication No.: US08236960B2Publication Date: 2012-08-07
- Inventor: Mikkel Boas Thygesen , Nathalie Schlienger , Bo-Ragnar Tolf , Carl-Magnus A. Andersson , Fritz Blatter , Jörg Berghausen
- Applicant: Mikkel Boas Thygesen , Nathalie Schlienger , Bo-Ragnar Tolf , Carl-Magnus A. Andersson , Fritz Blatter , Jörg Berghausen
- Applicant Address: US CA San Diego
- Assignee: ACADIA Pharmaceuticals Inc.
- Current Assignee: ACADIA Pharmaceuticals Inc.
- Current Assignee Address: US CA San Diego
- Agency: Jones Day
- Main IPC: C07D211/56
- IPC: C07D211/56 ; A61K31/445
Abstract:
Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl) -N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2 -methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
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