Invention Grant
US08236976B2 Processes for highly enantio- and diastereoselective synthesis of acyclic epoxy alcohols and allylic epoxy alcohols
有权
高度对映异构和非对映选择性合成无环环氧醇和烯丙基环氧醇的方法
- Patent Title: Processes for highly enantio- and diastereoselective synthesis of acyclic epoxy alcohols and allylic epoxy alcohols
- Patent Title (中): 高度对映异构和非对映选择性合成无环环氧醇和烯丙基环氧醇的方法
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Application No.: US10592075Application Date: 2005-03-09
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Publication No.: US08236976B2Publication Date: 2012-08-07
- Inventor: Patrick Walsh , Alice E. Lurain , Ann R. Kelly , Aaron G. Maestri
- Applicant: Patrick Walsh , Alice E. Lurain , Ann R. Kelly , Aaron G. Maestri
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Dann, Dorfman, Herrell and Skillman, P.C.
- Agent Patrick J. Hagan
- International Application: PCT/US2005/007778 WO 20050309
- International Announcement: WO2005/087755 WO 20050922
- Main IPC: C07D301/03
- IPC: C07D301/03 ; C07D301/14
Abstract:
The inventive subject matter relates to novel processes for making an epoxy alcohol from an aldehyde, comprising the steps of: (a) adding (i) an organozinc compound or (ii) divinylzinc compound and an diorganozinc compound to said aldehyde in the presence of a first catalyst to form an allylic alkoxide compound; and (b) epoxidizing said allylic alkoxide compound in the presence of an oxidant and a second catalyst.
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