Invention Grant
US08237015B2 Methods and compositions for an integrated dual site-specific recombination system for producing environmentally safe and clean transgenic plants
有权
用于生产环境安全和清洁的转基因植物的综合双位点特异性重组系统的方法和组合物
- Patent Title: Methods and compositions for an integrated dual site-specific recombination system for producing environmentally safe and clean transgenic plants
- Patent Title (中): 用于生产环境安全和清洁的转基因植物的综合双位点特异性重组系统的方法和组合物
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Application No.: US12174066Application Date: 2008-07-16
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Publication No.: US08237015B2Publication Date: 2012-08-07
- Inventor: Hong Luo
- Applicant: Hong Luo
- Applicant Address: US SC Clemson
- Assignee: Clemson University Research Foundation
- Current Assignee: Clemson University Research Foundation
- Current Assignee Address: US SC Clemson
- Agency: Myers Bigel Sibley & Sajovec, PA
- Main IPC: C12N15/82
- IPC: C12N15/82 ; A01H5/00 ; A01H5/10
Abstract:
The present invention is directed to the use of multiple site-specific recombination systems for use in transgene containment in plants. More specifically, the present invention describes coordinated excisional DNA recombination by multiple (e.g., dual) recombinases to achieve excision of unwanted transgenic DNA as well as recombinase-coding sequences themselves by self-excision. Further, the simultaneous use of multiple site-specific recombination systems in combination with controllable total sterility technology (i.e., no or reduced sexual reproduction), provides the production of environmentally safe, clean transgenic plants, enhancing the capability and public acceptance of transgenic technology for plant trait modification.
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