One or more carrier signals in a multiple-carrier UE transmitter are frequency-adjusted to account for an estimated error in the separation frequency between the transmitted carrier signals. The adjustment is applied when generating the UL signals for the respective carrier frequencies in digital baseband of the UE. In one embodiment, one or more of the modulators that apply the carrier separation frequency additionally apply a frequency correction. In another embodiment, first mixers apply the carrier separation frequency to each different carrier signal. One or more carrier signal paths include a second mixer applying a frequency correction to the carrier signal. The RF modulation frequency may also be adjusted to partially compensate for the estimated carrier separation frequency error.