The present invention provides a method for enhancing reliability of information transmission by (a) establishing a matrix based on the length of bits of valid information in frame time slots; and creating a new matrix by presetting Error Correction Coding (ECC) for rows and columns of said matrix; (b) adopting the 1st Interleaving method to re-allocate bits which have been processed twice by using said ECC in said new matrix, to both ends of said frame time slots; and (c) adopting the 2nd Interleaving method to re-allocate the remaining bits in said new matrix to the middle of said frame time slots. After processed like this, the anti-interfering ability of the bits at both ends of TDMA frame time slot can be significantly enhanced, and the bit-error rate is decreased most, and all redundancy bits of Hamming codes can be arrayed at both ends of TDMA frame time slot.