A support frame of glass brick wall has multiple horizontal beams, multiple vertical beams and multiple side bars. Each of the horizontal beams and the vertical beams has a body, two side wings respectively and longitudinally formed on and protruding from two edges of the body, and two lamp slots respectively and longitudinally formed on and recessed from two sides of the body. Each of the vertical beams is securely mounted between two adjacent glass bricks in a corresponding row of glass bricks with adhesive. Each of the horizontal beams is securely mounted on a top of a corresponding row of glass bricks with adhesive. Two of the side bars are securely mounted on two edge sides of the glass brick wall. Each of the side bars has openings to replace light strips mounted in the lamp slots. Accordingly, the support frame provides a clean and easy lamp replacement solution.