An embodiment of a device in accordance with the present invention is adapted to be positioned at least partially in a mouth of a user to reduce resistance of air flow in the oral pharyngeal region and to improve anatomic and functional relationships of the oral pharyngeal structure. The device comprises a base unit adapted to be removably mounted on a lower jaw of the mouth, a pair of tongue positioner guides, each tongue positioner guide connected at a proximal end to the base unit, and a pair of tongue positioners, each connected with a distal end of a corresponding tongue positioner guide. When the base unit is mounted on the lower jaw, the tongue positioners are adapted to be arranged beneath a tongue of the mouth so that the tongue is urged against a soft palette of the mouth to thereby reduce resistance of air flow in the oral pharyngeal region and improve anatomic and functional relationships of the oral pharyngeal structure.