A tamper evident product distribution pouch especially well-suited for pharmaceuticals is provided, which is made from a single sheet of folded and sealed flexible plastic in a simplified folding and heat-sealing operation that reduces manufacturing steps. The tamper evident pharmaceutical pouch includes a header containing an arrangement of mounting holes and a slot for use as a handle. A pouch is formed by folding over the sheet of material and heat sealing the edges along the length of the pouch. The opening of the pouch adjacent the header. This opening is covered by a flap that extends down from the header over the opening. The flap is not sealed along the edges and can be completely pivoted away from the opening. Adhesive is placed on the flap that contacts the front of the pouch to close and seal the pouch opening.