A chest compression system and method of use for respiratory therapies such as cystic fibrosis, including an air flow generator, a pulse frequency control component having a fan blade for producing a series of air pulses communicated to a patient-worn garment during a therapy session. The system further includes one or more patient physiologic sensors capable of capturing patient information during the therapy session. The sensors may include a blood oximeter or a mouthpiece used to evaluate pulmonary function. An airway congestion monitoring system provides airway and lung congestion trend analysis. Adjustments are made to the series of air pulses based on a patient's therapy session data.