An angioplasty device for insertion into an artery having undesired deposits includes a guide wire for insertion into the artery; an elongated flexible catheter for insertion into the artery over the guide wire, the catheter having a proximal end, a distal end, and one or more lumens extending longitudinally therethrough; an energizable ultrasonic transducer inside the distal end of the guide wire; an inflatable balloon overlying the catheter and the transducer such that when the transducer is energized, energy from the transducer is transmitted through the balloon to the deposits.