Invention Grant
US08257755B2 Metabolic syndrome-improving agent and medicine, supplement, functional food and food additive containing the same
失效
代谢综合征改善剂和药物,补充剂,功能性食品和含有该食品的食品添加剂
- Patent Title: Metabolic syndrome-improving agent and medicine, supplement, functional food and food additive containing the same
- Patent Title (中): 代谢综合征改善剂和药物,补充剂,功能性食品和含有该食品的食品添加剂
-
Application No.: US11795638Application Date: 2006-01-20
-
Publication No.: US08257755B2Publication Date: 2012-09-04
- Inventor: Takao Sasaki , Masamichi Yano
- Applicant: Takao Sasaki , Masamichi Yano
- Applicant Address: JP Kyoto
- Assignee: ARKRAY, Inc.
- Current Assignee: ARKRAY, Inc.
- Current Assignee Address: JP Kyoto
- Agency: Morgan, Lewis & Bockius LLP
- Priority: JP2005-014385 20050121
- International Application: PCT/JP2006/300865 WO 20060120
- International Announcement: WO2006/077975 WO 20060727
- Main IPC: A61K36/752
- IPC: A61K36/752 ; A61K31/235

Abstract:
A metabolic syndrome relieving agent that is free from a problem of side effects and can be taken for a long term is provided. Bergamottin is used as an agent for relieving a metabolic syndrome. Since bergamottin has functions of activating PPARα and PPARγ, promoting the secretion of adiponectin in adipocytes and inhibiting the generation of VLDLs in hepatic cells, it is possible to prevent or treat diseases such as insulin resistance, hyperinsulinism, type 2 diabetes, obesity, visceral fat obesity, hypertension, hyperlipemia, arteriosclerosis and the like and thus prevent or treat the metabolic syndrome. Also, as understood from the fact that citrus fruits such as a grapefruit or the like containing bergamottin have been eaten for many years, they have no problems in terms of safety and have a low calorie content, and therefore, they can be taken for a long term. Further, since bergamottin is tasteless and odorless, it does not impair the unique taste of a food when added to this food, so that it can be added to foods and taken.
Public/Granted literature
Information query