Invention Grant
- Patent Title: Compositions and methods for modulation of LMNA expression
- Patent Title (中): LMNA表达调控的组成和方法
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Application No.: US12090847Application Date: 2006-10-17
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Publication No.: US08258109B2Publication Date: 2012-09-04
- Inventor: C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
- Applicant: C. Frank Bennett , Kenneth W. Dobie , Susan M. Freier , Stanley T. Crooke
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Jones Day
- International Application: PCT/US2006/041018 WO 20061017
- International Announcement: WO2007/047913 WO 20070426
- Main IPC: C12N15/11
- IPC: C12N15/11
Abstract:
Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.
Public/Granted literature
- US20090156526A1 COMPOSITIONS AND METHODS FOR MODULATION OF LMNA EXPRESSION Public/Granted day:2009-06-18
Information query
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