Invention Grant
- Patent Title: Fused bicyclic compound
- Patent Title (中): 稠合双环化合物
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Application No.: US12671479Application Date: 2008-07-21
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Publication No.: US08258131B2Publication Date: 2012-09-04
- Inventor: Yoichi Takahashi , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iijima
- Applicant: Yoichi Takahashi , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iijima
- Applicant Address: JP Osaka
- Assignee: Mitsubishi Tanabe Pharma Corporation
- Current Assignee: Mitsubishi Tanabe Pharma Corporation
- Current Assignee Address: JP Osaka
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2007-200264 20070801
- International Application: PCT/JP2008/063751 WO 20080721
- International Announcement: WO2009/017190 WO 20090205
- Main IPC: C07D265/16
- IPC: C07D265/16 ; A61K31/352 ; A61K31/353

Abstract:
The present invention provides a novel fused bicyclic compound having an affinity to a receptor of mineral corticoid (MR), shown by the formula [I]: wherein the ring A is a benzene ring having a substituent R1, fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R1, R1 is an alkylsulfonylamino group etc., R2 and R3 are (a) the same of different and a hydrogen atom, an alkyl group or a substituted or unsubstituted aryl group, (b) combined each other to form an oxo group or (c) combined each other at its terminal together with the adjacent carbon atom to form a cycloalkyl group, X is a group of ═N—, ═C(R4)— or —CH(R4)—, R4 is (a) a hydrogen atom, (b) a cyano group, (c) a halogen atom, (d) an alkyl group, (e) an alkenyl group, (f) a cycloalkyl group (g) an alkanoyl group, (h) a carbamoyl group or (i) a cycloalkenyl group, Ar is an optionally substituted aromatic cyclic group and a dotted line means presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, which is useful as an antihypertensive agent etc.
Public/Granted literature
- US20100204218A1 FUSED BICYCLIC COMPOUND Public/Granted day:2010-08-12
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