Invention Grant
- Patent Title: Quinolizidinone M1 receptor positive allosteric modulators
- Patent Title (中): 喹诺酮酮M1受体阳性变构调节剂
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Application No.: US12738208Application Date: 2008-10-15
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Publication No.: US08258135B2Publication Date: 2012-09-04
- Inventor: Ronald K. Chang , Scott D. Kuduk
- Applicant: Ronald K. Chang , Scott D. Kuduk
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; Gerard M. Devlin
- International Application: PCT/US2008/011752 WO 20081015
- International Announcement: WO2009/051715 WO 20090423
- Main IPC: A61K31/498
- IPC: A61K31/498 ; A61K31/4545 ; C07D455/02 ; C07D241/42 ; A61P25/00 ; A61P29/00
Abstract:
The present invention is directed to spiropiperidine compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
Public/Granted literature
- US20100222355A1 QUINOLIZIDINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS Public/Granted day:2010-09-02
Information query
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