Invention Grant
US08258162B2 Catechol derivative, pharmaceutical composition containing the same, use of the catechol derivative, and use of the pharmaceutical composition
有权
儿茶酚衍生物，含有它们的药物组合物，儿茶酚衍生物的用途和药物组合物的用途
- Patent Title: Catechol derivative, pharmaceutical composition containing the same, use of the catechol derivative, and use of the pharmaceutical composition
- Patent Title (中): 儿茶酚衍生物，含有它们的药物组合物，儿茶酚衍生物的用途和药物组合物的用途
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Application No.: US13002475Application Date: 2009-06-26
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Publication No.: US08258162B2Publication Date: 2012-09-04
- Inventor: Takehiro Ishikawa , Satoko Kobayashi , Hitoshi Inoue , Yasunori Ueno , Masako Yoshida , Nobuyuki Tanaka
- Applicant: Takehiro Ishikawa , Satoko Kobayashi , Hitoshi Inoue , Yasunori Ueno , Masako Yoshida , Nobuyuki Tanaka
- Applicant Address: JP Nagano
- Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee: Kissei Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Nagano
- Agency: Sughrue Mion, PLLC
- Priority: JP2008-175567 20080704
- International Application: PCT/JP2009/061685 WO 20090626
- International Announcement: WO2010/001821 WO 20100107
- Main IPC: A61K31/04
- IPC: A61K31/04 ; A61K31/426 ; A61K31/42 ; A61K31/381 ; C07C205/06 ; C07D277/20 ; C07D261/06 ; C07D333/02
Abstract:
The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or the like; R4 is cyano, lower alkoxycarbonyl, carboxy or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
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