Invention Grant
US08258172B2 Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof
有权
可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法
- Patent Title: Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof
- Patent Title (中): 可用于降低淀粉样蛋白前体蛋白和治疗痴呆的药剂及其使用方法
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Application No.: US12841888Application Date: 2010-07-22
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Publication No.: US08258172B2Publication Date: 2012-09-04
- Inventor: Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
- Applicant: Nigel H. Greig , Karen T. Y. Shaw , Qiang-Sheng Yu , Harold W. Holloway , Tada Utsuki , Timothy T. Soncrant , Donald K. Ingram , Arnold Brossi , Anthony Giordano , Gordon Powers , Diane M. Davidson , Michael Sturgess
- Applicant Address: US CA Novato US MD Bethesda
- Assignee: Raptor Pharmaceutical Corp,National Institutes of Health (NIH)
- Current Assignee: Raptor Pharmaceutical Corp,National Institutes of Health (NIH)
- Current Assignee Address: US CA Novato US MD Bethesda
- Agency: Riverside Law LLP
- Main IPC: A61K31/40
- IPC: A61K31/40
Abstract:
The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease βAPP production.
Public/Granted literature
- US20110021594A1 Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof Public/Granted day:2011-01-27
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