Invention Grant
- Patent Title: Glycine transporter-1 inhibitors
- Patent Title (中): 甘氨酸转运蛋白-1抑制剂
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Application No.: US12746755Application Date: 2008-12-11
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Publication No.: US08258306B2Publication Date: 2012-09-04
- Inventor: Stephen A. Hitchcock , Wenyuan Qian , Albert Amegadzie
- Applicant: Stephen A. Hitchcock , Wenyuan Qian , Albert Amegadzie
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Elsa D. Lemoine
- International Application: PCT/US2008/013596 WO 20081211
- International Announcement: WO2009/075857 WO 20090618
- Main IPC: C07D211/34
- IPC: C07D211/34
Abstract:
The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
Public/Granted literature
- US20100298341A1 Glycine Transporter-1 Inhibitors Public/Granted day:2010-11-25
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