Invention Grant
- Patent Title: Process for forming amorphous atorvastatin
- Patent Title (中): 形成无定形阿托伐他汀的方法
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Application No.: US13079376Application Date: 2011-04-04
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Publication No.: US08258315B2Publication Date: 2012-09-04
- Inventor: Antone J deBettencourt, III , Peter R. Rose , Evgenyi Shalaev , George J. Quallich , Carl B. Ziegler, Jr.
- Applicant: Antone J deBettencourt, III , Peter R. Rose , Evgenyi Shalaev , George J. Quallich , Carl B. Ziegler, Jr.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agent Francis J. Tinney
- Main IPC: C07D207/00
- IPC: C07D207/00 ; A61K31/40
Abstract:
A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.
Public/Granted literature
- US20110237642A1 Process for Forming Amorphous Atorvastatin Public/Granted day:2011-09-29
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