Invention Grant
- Patent Title: Hydroxylation of β-dicarbonyls with zirconium catalysts
- Patent Title (中): 用锆催化剂羟基化羰基
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Application No.: US13048999Application Date: 2011-03-16
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Publication No.: US08258345B2Publication Date: 2012-09-04
- Inventor: Albert Loren Casalnuovo
- Applicant: Albert Loren Casalnuovo
- Applicant Address: US DE Wilmington
- Assignee: E I du Pont de Nemours and Company
- Current Assignee: E I du Pont de Nemours and Company
- Current Assignee Address: US DE Wilmington
- Agent Craig L. Hillemann
- Main IPC: C07C211/01
- IPC: C07C211/01

Abstract:
The present invention pertains to a process for preparing a compound of Formula I that is achiral, racemic or enantiomerically enriched at the hydroxylation center indicated by * comprising contacting a compound of Formula II with an oxidant selected from oxygen, hydrogen peroxide, peracids or alkyl hydroperoxides in the presence of a zirconium complex, wherein R1, R2 and R3 are as defined in the disclosure. This invention also pertains to zirconium complexes useful in this procedure comprising zirconium and a ligand of Formula III or its enantiomer wherein J, R6 and n are as defined in the disclosure. This invention further pertains to a compound of Formula III or its enantiomer.
Public/Granted literature
- US20110196175A1 Hydroxylation of Beta-Dicarbonyls with Zirconium Catalysts Public/Granted day:2011-08-11
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