This invention provides a photographing module with optical zoom, which at least includes a focusing lens assembly, a zoom lens assembly, a focusing lens actuator, a zoom lens actuator, a photo sensor and a vibration sensor. The focusing lens actuator at least includes a first movable member, a first fixed member and a first electric unit, wherein the first electric unit can drive the first movable member to proceed axial displacement and incline at an angle with respect to at least one axis. The zoom lens actuator at least includes a second movable member, a second fixed member and a second electric unit, wherein the second electric unit can drive the second movable member to proceed axial displacement. Alternatively, the axial inclination driven by the first electric unit of the focusing lens actuator may be driven by the second electric unit of the zoom lens actuator.