An apparatus and method for Time-Varying Cyclic Delay Diversity (TV-CDD) in a wireless communication system are provided. The method includes, if there is a signal of an antenna path to be transmitted, determining if a current time corresponds to a preamble zone within a frame and, if the current time corresponds to the preamble zone within the frame, shifting a partial antenna path signal forward compared to a reference timing and shifting a remaining partial antenna path signal equally or backward compared to the reference timing.