In a wireless telecommunications network, a Code Division Multiple Access (CDMA) scheme is applied to data to encode it. The encoded data transmitted in the uplink using an Orthogonal Frequency Division Multiplexing (OFDM) frame structure including a cyclic prefix (CP). The CDMA encoded data may be time multiplexed with Single Carrier-Frequency Division Multiple Access (SC-FDMA) transmissions. The CDMA transmissions may be used for relatively small payloads, such as those associated with voice traffic and control signals, and the SC-FDMA transmissions used for higher date rate transmissions. This enables autonomous transmission, without scheduling, for smaller payloads. A transmitter includes a selector 3 for performing time multiplexing in the uplink, the required mode being indicated by the Hybrid Automatic Repeat Request (HARQ) ID. A first branch 1 carries SC-FDMA data and a second branch 2 carries data to be transmitted as a CDMA scheme. A CAZAC code may be used in encoding the CDMA data.