A system and a method of time information synchronization as well as related apparatuses are disclosed to improve precision of frequency synchronization or time synchronization. The application port subsystem in the information synchronization system is configured to: generate at least one local clock according to a locally running real-time clock, and provide the local clock for a core subsystem; and the core subsystem is configured to: select a best system clock according to attributes of the clock provided by the application port subsystem, and send the best system clock to the application port subsystem, where: the application port subsystem calibrates the real-time clock according to the best system clock provided by the core subsystem in order to perform frequency synchronization and/or time synchronization. The embodiments of the present invention improve the precision of frequency synchronization or time synchronization effectively.