A power control scheme for an enhanced Universal Mobile Telecommunications System (UMTS) Terrestrial Radio Access (E-UTRA) physical uplink shared channel (PUSCH) is disclosed. In a first embodiment, when an uplink grant is configured for accumulation commands, the wireless transmit/receive unit (WTRU) combines the accumulation commands received in both the scheduling grant and the transmit power control physical downlink control channel. In a second embodiment, when an uplink grant is configured for absolute commands, the WTRU resets the accumulation control function immediately after receiving each absolute transmit power control command and then combines the absolute power control with the accumulation power control.