A system and a method for analysis of ECG curvature, which system involves a mathematical analysis comprising the following features where a number of different parameters are isolated and stored in a computer, where a first number of parameters are selected from at least one main group, where the selected parameters are combined in at least a first mathematical analysis. It is the object of the invention to improve mathematical analysis of ECG curvature particular for complex parts of the curvature such as notches or concavities. This can be achieved by selecting parameters from groups of symmetry, flatness, duration and/or complexity, using the parameters as input to an algorithm, where concavity intervals are evaluated on subsegments of the ECG segment and form the basis of up and downwards concavity quantification, where the system based on an algorithm detects and quantifies concavity on ECG curvatures.