The present invention provides systems and methods for maintaining site persistence in a hierarchical Global Server Load Balancing (GSLB) deployment. Via configuration of GSLB services locally and remotely on each of the GSLB appliances and LB appliances at a site, a site appliance identifies and associates requests from the GSLB with the site. Furthermore, the site appliance may receive a GSLB cookie with the client request and confirms the request is from the expected GSLB in the site hierarchy. When the load balancers receives a response from a server, the appliance may include the GSLB cookie with the response back to the client. The appliance may also include an LB cookie to identify the server selected by the LB. When the client sends another request, the request may include the GSLB and LB cookie. With this information, the GSLB and LB appliance may maintain site persistence for the client as well as server persistence at the site.