An object of the present invention is to provide a heavy-duty pneumatic tire that is capable of suppressing deterioration by oxidation at a portion of a high heat generation in a bead portion, and that is excellent in sustainability of inner pressure holding performance as well as in durability. The heavy-duty pneumatic tire of the present invention includes a carcass and an inner liner disposed closer to the center of the tire than the carcass. The heavy-duty pneumatic tire is characterized in that one of a thermoplastic resin and a thermoplastic elastomer composition containing a blend of a thermoplastic resin with an elastomer is disposed at a position closer to the center than the carcass in the bead portion in such a manner as to wrap at least a region extending to a front end PB of a bead toe or a region extending further from the front end PB of the bead toe to a portion beneath the bead, and the one of the thermoplastic resin and the thermoplastic elastomer composition containing the blend of the thermoplastic resin with the elastomer overlaps the inner liner by at least 2 mm in a tire width direction.