Invention Grant
US08268550B2 Compositions and methods for identification of PARP function, inhibitors, and activators
有权
用于鉴定PARP功能，抑制剂和活化剂的组合物和方法
- Patent Title: Compositions and methods for identification of PARP function, inhibitors, and activators
- Patent Title (中): 用于鉴定PARP功能，抑制剂和活化剂的组合物和方法
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Application No.: US12459212Application Date: 2009-06-26
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Publication No.: US08268550B2Publication Date: 2012-09-18
- Inventor: Paul Chang , Sejal Vyas
- Applicant: Paul Chang , Sejal Vyas
- Applicant Address: US MA Cambridge
- Assignee: Massachusetts Institute of Technology
- Current Assignee: Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge
- Agency: Clark & Elbing LLP
- Agent Kristina Bieker-Brady
- Main IPC: G01N33/53
- IPC: G01N33/53
Abstract:
The invention provides nucleic acids encoding PARP fusion proteins, PARP fusion proteins, antibodies that bind to one or more of these PARP fusion proteins, and transgenic cells expressing one or more PARP fusion proteins. The invention also provides methods for identifying an agent as a specific PARP inhibitor or activator requiring contacting one or more PARP fusion proteins with a labeled nicotinamide adenine dinucleotide substrate and the agent and measuring the amount of labeled of ADP-ribose covalently attached to the one or more PARP fusion proteins. The invention also provides methods for identifying an agent that specifically binds to one or more PARP fusion proteins and methods for quantitating the level of one or more PARP proteins in a sample.
Public/Granted literature
- US20100330583A1 Compositions and methods for identification of PARP function, inhibitors, and activators Public/Granted day:2010-12-30
Information query
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