Invention Grant
US08268591B2 Compositions and methods for producing inhibitors of vascular endothelial growth factor activity
有权
用于产生血管内皮生长因子活性抑制剂的组合物和方法
- Patent Title: Compositions and methods for producing inhibitors of vascular endothelial growth factor activity
- Patent Title (中): 用于产生血管内皮生长因子活性抑制剂的组合物和方法
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Application No.: US13096734Application Date: 2011-04-28
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Publication No.: US08268591B2Publication Date: 2012-09-18
- Inventor: Terri Lynn Davis-Smyth , Helen Hsifei Chen , Leonard Presta , Napoleone Ferrara
- Applicant: Terri Lynn Davis-Smyth , Helen Hsifei Chen , Leonard Presta , Napoleone Ferrara
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Jones Day
- Main IPC: C12N15/62
- IPC: C12N15/62 ; C12N15/63 ; C07H21/00
Abstract:
The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.
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