Invention Grant
US08268621B2 Methods of deriving definitive endoderm cells from pluripotent parthenogenetic stem cells
有权
从多能单性干细胞中得到确定性内胚层细胞的方法
- Patent Title: Methods of deriving definitive endoderm cells from pluripotent parthenogenetic stem cells
- Patent Title (中): 从多能单性干细胞中得到确定性内胚层细胞的方法
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Application No.: US12629813Application Date: 2009-12-02
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Publication No.: US08268621B2Publication Date: 2012-09-18
- Inventor: Nikolay Turovets , Larisa Agapova , Andrey Semechkin , Jeffrey Janus
- Applicant: Nikolay Turovets , Larisa Agapova , Andrey Semechkin , Jeffrey Janus
- Applicant Address: US CA San Diego
- Assignee: International Stem Cell Corporation
- Current Assignee: International Stem Cell Corporation
- Current Assignee Address: US CA San Diego
- Agency: DLA Piper LLP (US)
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02
Abstract:
The present invention provides a method of generating definitive endoderm, mesoderm, or ectoderm cells. The method includes culturing embryonic stem cells, parthenogenetic cells, or induced pluripotent stem cells in the presence of a demethylation agent, a histone deacetylase inhibitor, or a combination thereof, and thereafter, culturing the stem cells in the absence of the agent or combination of agents, to produce definitive endoderm cells, mesoderm, or ectoderm cells.
Public/Granted literature
- US20100173414A1 Methods of Deriving Differentiated Cells from Stem Cells Public/Granted day:2010-07-08
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