Sensor devices and sensing methods are provided. A sensor device is provided two flow channels, each comprising a sensor, and analyte flow is alternated between the two channels such that the sensors alternately serve as a sensor and a reference, thereby increasing accuracy of the sensors. The device is useful, for example, in chemical sensing using a variety of sensor types including without limitation: chemiresistors, gravimetric sensors, optical sensors, among others. Related sensing methods also are provided.