Invention Grant
US08268773B2 Methods of treating multiple sclerosis (MS) using an IL-17A and IL-17F antagonist
有权
使用IL-17A和IL-17F拮抗剂治疗多发性硬化（MS）的方法
- Patent Title: Methods of treating multiple sclerosis (MS) using an IL-17A and IL-17F antagonist
- Patent Title (中): 使用IL-17A和IL-17F拮抗剂治疗多发性硬化（MS）的方法
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Application No.: US13015304Application Date: 2011-01-27
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Publication No.: US08268773B2Publication Date: 2012-09-18
- Inventor: Scott R. Presnell , Steven K. Burkhead , Steven D. Levin , Rolf E. Kuestner , Zeren Gao , Stephen R. Jaspers , Janine Bilsborough
- Applicant: Scott R. Presnell , Steven K. Burkhead , Steven D. Levin , Rolf E. Kuestner , Zeren Gao , Stephen R. Jaspers , Janine Bilsborough
- Applicant Address: US WA Seattle
- Assignee: ZymoGenetics, Inc.
- Current Assignee: ZymoGenetics, Inc.
- Current Assignee Address: US WA Seattle
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Jill Gorny Sloper, Esq.
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17F, IL-17A, or both IL-17A and IL-17F polypeptide molecules. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. ZcytoR14 is a common receptor for IL-17A and IL-17F. The present invention includes soluble ZcytoR14, anti-ZcytoR14 antibodies and binding partners, as well as methods for antagonizing IL-17F, IL-17A or both IL-17A and IL-17F using such soluble receptors, antibodies and binding partners.
Public/Granted literature
- US20110177083A1 SOLUBLE ZCYTOR14, ANTI-ZCYTOR14 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION Public/Granted day:2011-07-21
Information query
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