Invention Grant
- Patent Title: Macrocylic oximyl hepatitis C protease inhibitors
- Patent Title (中): 大蓖麻丙型肝炎蛋白酶抑制剂
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Application No.: US12016643Application Date: 2008-01-18
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Publication No.: US08268776B2Publication Date: 2012-09-18
- Inventor: Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
- Applicant: Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
- Applicant Address: US MA Watertown
- Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Edwards Wildman Palmer LLP
- Agent Jeffrey D. Hsi; Weiying Yang
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Public/Granted literature
- US20080181868A1 MACROCYLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS Public/Granted day:2008-07-31
Information query
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