Invention Grant
- Patent Title: Low density lipoprotein receptor-mediated siRNA delivery
- Patent Title (中): 低密度脂蛋白受体介导的siRNA递送
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Application No.: US13150317Application Date: 2011-06-01
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Publication No.: US08268798B2Publication Date: 2012-09-18
- Inventor: Jon E. Chatterton
- Applicant: Jon E. Chatterton
- Applicant Address: US TX Fort Worth
- Assignee: Alcon Research, Ltd.
- Current Assignee: Alcon Research, Ltd.
- Current Assignee Address: US TX Fort Worth
- Agent Jason J. Derry
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04 ; C07K5/00
Abstract:
The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a low density lipoprotein receptor (LDLR) or LDLR family member. Therapeutic uses for the conjugates are also provided.
Public/Granted literature
- US20110230410A1 LOW DENSITY LIPOPROTEIN RECEPTOR-MEDIATED siRNA DELIVERY Public/Granted day:2011-09-22
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