Invention Grant
US08268799B2 Compositions and methods for inhibiting expression of the HAMP gene
有权
用于抑制HAMP基因表达的组合物和方法
- Patent Title: Compositions and methods for inhibiting expression of the HAMP gene
- Patent Title (中): 用于抑制HAMP基因表达的组合物和方法
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Application No.: US13184087Application Date: 2011-07-15
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Publication No.: US08268799B2Publication Date: 2012-09-18
- Inventor: Tomoko Nakayama , Anke Geick , Pamela Tan , Herbert Y. Lin
- Applicant: Tomoko Nakayama , Anke Geick , Pamela Tan , Herbert Y. Lin
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Fenwick & West LLP
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/02 ; C07H21/04
Abstract:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the HAMP gene (HAMP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the HAMP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HAMP gene expression and the expression of the HAMP gene using the pharmaceutical composition.
Public/Granted literature
- US20110269823A1 Compositions And Methods For Inhibiting Expression Of The HAMP Gene Public/Granted day:2011-11-03
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