Invention Grant
- Patent Title: Compositions and methods for inhibiting TGF-β
- Patent Title (中): 用于抑制TGF-β的组合物和方法
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Application No.: US11653679Application Date: 2007-01-16
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Publication No.: US08268857B2Publication Date: 2012-09-18
- Inventor: Robert M. Scarborough , Anjali Pandey , Meenakshi S. Venkatraman
- Applicant: Robert M. Scarborough , Anjali Pandey , Meenakshi S. Venkatraman
- Applicant Address: US MA Cambridge
- Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Millennium Pharmaceuticals, Inc.
- Main IPC: A61K31/4745
- IPC: A61K31/4745 ; C07D471/04 ; A61P25/28 ; A61P9/10 ; A61P13/12 ; A61P19/02
Abstract:
This invention provides compounds that are useful for treating patients having a TGF-β-mediated disease, particularly an ALK5-mediated disease. The compounds are represented by formula I: wherein: a-b is CH2CH2, CH2CH2CH2, CH═CH, CH═N, or N═CH; Z is N or C—F; and G is C1-6 aliphatic or a phenyl, naphthyl, or 5-6 membered heteroaryl ring.
Public/Granted literature
- US20070142408A1 Compositions and methods for inhibiting TGF-Beta Public/Granted day:2007-06-21
Information query
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