Invention Grant
- Patent Title: Quaternary alkyl ammonium bacterial efflux pump inhibitors and therapeutic uses thereof
- Patent Title (中): 季铵烷基铵细菌外排泵抑制剂及其治疗用途
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Application No.: US12116164Application Date: 2008-05-06
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Publication No.: US08268865B2Publication Date: 2012-09-18
- Inventor: Tomasz Glinka , Olga Lomovskaya , Keith Bostian , David M. Wallace
- Applicant: Tomasz Glinka , Olga Lomovskaya , Keith Bostian , David M. Wallace
- Applicant Address: US CA San Diego
- Assignee: Rempex Pharmaceuticals, Inc.
- Current Assignee: Rempex Pharmaceuticals, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Knobbe, Martens, Olson & Bear LLP
- Main IPC: C07D215/38
- IPC: C07D215/38 ; A61K31/04
Abstract:
Disclosed are compounds having at least one quaternary alkyl ammonium functionality. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.
Public/Granted literature
- US20120165276A1 QUATERNARY ALKYL AMMONIUM BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF Public/Granted day:2012-06-28
Information query
