Invention Grant
US08268884B2 Derivatives of substituted tartaric acid and usage for preparing beta-secretase inhibitors
有权
取代酒石酸的衍生物和用于制备β-分泌酶抑制剂的用途
- Patent Title: Derivatives of substituted tartaric acid and usage for preparing beta-secretase inhibitors
- Patent Title (中): 取代酒石酸的衍生物和用于制备β-分泌酶抑制剂的用途
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Application No.: US12521425Application Date: 2007-02-05
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Publication No.: US08268884B2Publication Date: 2012-09-18
- Inventor: Song Li , Guochao Liao , Junhai Xiao , Aihua Nie , Lili Wang , Wu Zhong , Zhibing Zheng
- Applicant: Song Li , Guochao Liao , Junhai Xiao , Aihua Nie , Lili Wang , Wu Zhong , Zhibing Zheng
- Applicant Address: CN Beijing
- Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- Current Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
- Current Assignee Address: CN Beijing
- Agency: Brinks Hofer Gilson & Lione
- Priority: CN200610156136 20061229
- International Application: PCT/CN2007/000389 WO 20070205
- International Announcement: WO2008/080268 WO 20080710
- Main IPC: A61K31/225
- IPC: A61K31/225 ; A61K31/235 ; C07C229/00
Abstract:
The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof: in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of β-amyloid peptide.
Public/Granted literature
- US20100331345A1 DERIVATIVES OF SUBSTITUTED TARTARIC ACID AND USAGE FOR PREPARING BETA-SECRETASE INHIBITORS Public/Granted day:2010-12-30
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