Invention Grant
US08268985B2 siRNA targeting amyloid beta (A4) precursor protein (APP)
有权
siRNA靶向淀粉样蛋白β（A4）前体蛋白（APP）
- Patent Title: siRNA targeting amyloid beta (A4) precursor protein (APP)
- Patent Title (中): siRNA靶向淀粉样蛋白β（A4）前体蛋白（APP）
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Application No.: US12924078Application Date: 2010-09-20
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Publication No.: US08268985B2Publication Date: 2012-09-18
- Inventor: Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
- Applicant: Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
- Applicant Address: US CO Lafayette
- Assignee: Dharmacon, Inc.
- Current Assignee: Dharmacon, Inc.
- Current Assignee Address: US CO Lafayette
- Agency: Dorf & Nelson LLP
- Agent Scott D. Locke, Esq.
- Main IPC: C07H21/04
- IPC: C07H21/04
Abstract:
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for APP.
Public/Granted literature
- US20110021382A1 siRNA targeting amyloid beta (A4) precursor protein (APP) Public/Granted day:2011-01-27
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