Invention Grant
- Patent Title: Process for the synthesis of HMG-CoA reductase inhibitors
- Patent Title (中): 合成HMG-CoA还原酶抑制剂的方法
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Application No.: US12088019Application Date: 2006-10-04
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Publication No.: US08269001B2Publication Date: 2012-09-18
- Inventor: Zdenko Casar
- Applicant: Zdenko Casar
- Applicant Address: SI Ljublijana
- Assignee: Lek Pharmaceuticals d.d.
- Current Assignee: Lek Pharmaceuticals d.d.
- Current Assignee Address: SI Ljublijana
- Agency: Luedeka Neely Group, P.C.
- Priority: EP05021706 20051005
- International Application: PCT/EP2006/009599 WO 20061004
- International Announcement: WO2007/039287 WO 20070412
- Main IPC: C07D239/00
- IPC: C07D239/00 ; C07D321/00
Abstract:
A novel synthesis of statins uses Wittig reaction of a heterocyclic core of statin with a lactonized side chain already possessing needed stereochemistry. Any separation of diastereoisomers is performed early in the course of synthesis.
Public/Granted literature
- US20080300406A1 Process for the Synthesis of Hmg-Coa Reductase Inhibitors Public/Granted day:2008-12-04
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