A multi-chip package structure is provided with a first chip, a substrate adjacent to the first chip, a plurality of contacts connecting the first chip and the substrate, a second chip disposed between the first chip and the substrate and connecting to the first chip, and a underfill film, wherein the underfill film covers the contact to isolate the contact from the second chip, wherein an empty space is defined by the second chip and the substrate so that the second chip does not contact the substrate.