A system and/or method to control access to secured compartments in a facility. Computers positioned throughout the facility are interfaced to respective locking mechanisms to operate the locking mechanism in response to access codes, which may be transmitted over the network. Additional steps may involve programming an authorization computer for providing access codes in whole or part for use with the computers. One or more access points may be functionally coupled to a computer system and/or to the locking mechanism and accessible to users for entry of requests for access to the secured compartment.