Transparent communication between iSCSI and FCoE end nodes is provided by a gateway device having iSCSI and FCoE network interfaces. The gateway allows end nodes of one protocol to communicate with end nodes of another protocol as if they were communicating with end nodes of the same protocol. The gateway accomplishes this by creating “ghost” end nodes for each protocol. For example, the gateway creates ghost iSCSI nodes corresponding to physical FCoE nodes, and ghost FCoE nodes corresponding to physical iSCSI nodes. A ghost end node of a particular protocol is able to communicate with native end nodes of that protocol as if it were a native end node, because the gateway translates packets sent from end nodes in their native protocol into the other protocol for receipt by corresponding ghost nodes, and vice versa.