Modified host bio-data includes biogenetic modeling, sequence engineering, material manufacturing, gene therapy, embedded sensing, programmable operation, tissue scaffolding, clinical trials, contamination checks, and host monitoring. Bio-data are managed for device malfunction or infectious release. Genetically programmable finite state module having partitions or multi-cavity may be accessed for embedded host biometric application. Electronic computer or functionally equivalent system or distributed systems for processing digital data serves to manage modified host data. Unique host identifier and modification indication are stored or accessed in authenticated manner. Modification may be structural tissue regeneration or genetic therapy. Host condition is monitored by accessing host identifier and modification indication, per sensor signal generated by embedded sensors, accessible by wireless communication, generated per request signal, and generated by silicon or quantum dot devices, each sensor partitioned separately in multi-partition device. Device is programmed to switch states of partitions. Sensor signal may indicate contamination. Sensor set corresponds with state device set of finite state machine, so state device indicates state per first sensor sensing host modification, and other state device indicates other state in response to second sensor sensing modification.